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modafinil will reduce the extent or effect of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.modafinil will reduce the extent or influence of fruquintinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If coadministration with moderate CYP3A4 inducers is unavoi